| CPE |
CPE activates the Erk/wnt pathways, while CPE-N interacts with HDACs in a protein complex in the nucleus, to recruit various cell cycle genes and metastatic genes, respectively. |
Key regulators of BC metastasis |
35988818 |
| KAI1 (CD82) |
no data available |
decreases BC metastasis |
34121877 |
| MEX3A |
via beta-catenin signaling pathway inhibition |
attenuates metastasis of breast cancer |
34425185 |
| TRAF4 |
downregulated levels targets RSK4 |
inhibits metastasis in breast cancer xenografts |
29684350 |
| 14-3-3Zeta (YWHAZ) |
HER2 overexpression |
promotes lymph node metastasis in invasive ductal carcinoma |
34560418 |
| ACC1 |
Acetylation |
Controls Breast Cancer Metastasis |
29056512 |
| ACKR4 and CCR7 |
significant negative and positive correlation with ACKR4 and CCR7, repsectively |
breast cancer metastasis |
34102193 |
| ACTN1 |
knockdown expression suppresseses Oroxylin A inactivate cancer-associated fibroblasts |
restrain breast cancer metastasis |
32492489 |
| AKT1 |
overexpressed |
promotes metastasis |
33531603 |
| AKT2 |
by regulating Beta-integrins, EMT proteins and F-actin |
promotes metastasis |
31752925 |
| AMACR |
|
Lymph Node Metastases |
36577560 |
| ARG2 |
T-cell depletion |
breast cancer brain metastasis |
33485843 |
| ASAP1 |
activates AKT |
accelerates metastasis |
35181478 |
| ASB13 |
through promoting SNAI2 degradation and relieving its transcriptional repression of YAP |
inhibits breast cancer metastasis |
32943576 |
| AXL |
AXL modulation of tumor microenvironment and immune response |
promotes metastasis |
32148495 |
| BACH1 |
|
Master Regulator of Breast Cancer Bone Metastasis |
22875853 |
| BCL11A |
represses MBNL1-directed splicing of ITGA6 |
promotes metastasis |
32576660 |
| BIRC5 |
varies in accordance with the stage of the disease |
promote lymph node metastasis |
30957048 |
| BIRC5-1 |
activates fibroblasts by up-regulating SOD1 |
promotes cancer proliferation and metastasis |
32709750 |
| BRCA1 |
high expression levels of GATA3 reduces EMT |
reduces metastasis |
34373738 |
| BRCA2 |
Mutations in the gene |
detect patterns and recurrence of CNS metastasis |
31581314 |
| BRM (SMARCA2) |
transcription of tight junction proteins |
BC metastasis |
30946989 |
| BTNL9 |
downregulated mediates P53/CDC25C, P53/GADD45 pathways |
decreased rate of BC meta |
33756341 |
| CA13 |
Increased expression |
decreased rate of BC meta |
33588197 |
| CACNG4 |
decreased levels modulate L-type VGCCs, regulate oncogenes like AKT2, HDAC3 and TSGs like RASA1 |
decreased BC metastasis |
32062352 |
| CAV1 |
expression of stromal CAV1 |
promotes axillary lymph node metastasis |
33531603 |
| CBX7 |
regulates Twist1/tphA2 pathway |
mediates migration and metastasis |
35843065 |
| CCL18 |
Targets PITPNM3 |
Promotes Breast Cancer Metastasis |
21481794 |
| CCL5 |
Macrophage-tumor cells crosstalk |
Promotes Breast Cancer Lung Metastasis |
32829009 |
| CD155 (PVR) |
T cell-derived interleukin-22-mediated expression suppress NK cell function |
promote Liver metastasis |
36630913 |
| CDCP1 |
DCP1 knockdown attenuated HGF-induced MET activation |
suppression of cell migration |
35085554 |
| CDH1 |
Inactivated gene |
lymph node metatsasis |
32301282 |
| CDK14 |
nhibition reduces mammary stem cell activity |
suppresses triple negative breast cancer progression |
36103813 |
| CFL1 |
via extracellular vesicles |
promotes metastasis in TNBC |
34678587 |
| CPEB2 |
Alternative Splicing |
Drives Metastasis of Triple Negative Breast Cancer |
26304115 |
| CTCF |
|
metastatic BC treatment |
34938908 |
| CTSL |
polyoma middle T oncogene driven breast cancer mouse model |
promoter of lung metastasis |
25957406 |
| CXCL12 |
CXCR4/CXCL12 signaling axis in breast cancer metastasis to the brain |
BC metastasis to brain |
18814042 |
| CXCL8 (IL8) |
enhances breast cancer metastasis |
Suppression by Danirixin |
33677254 |
| CXCR2 |
suppression of AKT1 and activation of COX2 |
promotes breast cancer metastasis |
28964785 |
| CXCR4 |
Overexpression of CXCR4 synergizes with LL-37 |
metastasis of breast cancer cells |
30251699 |
| DAAM1 |
Overexpressed |
Lymph-node metastasis |
31757662 |
| DCLK1 |
|
regulates growth and metastasis in basal-like breast cancer |
Reference Link |
| DDR2 |
Loss of DDR2 in MSCs (multipotent stromal cells) |
Metastasis Growth |
28147276 |
| DEK |
creating an immunodeficient tumour milieu with M2 tumour-associated macrophages |
increasing tumour metastasis |
36535490 |
| DEPTOR |
through Coupling to Survivin Expression |
Enhances Triple-Negative Breast Cancer Metastasis |
26952810 |
| DFNA5 (GSDME) |
Methylation |
lymph node metastasis in human breast cancer |
18346456 |
| DHRS2 |
downregulated levels |
decreased rate of BC meta |
Reference Link |
| DLL4 and JAG1-1 |
overexpressed |
promote metastasis |
32111499 |
| DLL4 and JAG1-2 |
by Engaging Notch Signaling in Bone Cells |
Promotes Osteolytic Bone Metastasis of Breast Cancer |
32111499 |
| DNAJB4 and CD81 |
metastasis inducer, knockdown of DNAJB4 leads to a decrease in migration |
impairs lung metastasis |
31221721 |
| DNAJB9 |
by promoting FBXO45-mediated degradation of ZEB1 |
suppresses the metastasis of triple-negative breast cancer |
33966034 |
| EF1-delta |
by regulating MMP-1 expression |
osteolytic metastasis of MDA-MB-231 |
21241837 |
| EGFR |
mutated (gain of function) |
promotes metastasis |
23986907 |
| EVI1 (MECOM) |
targets TIMP2 and decreases the expression levels |
increases metastasis |
33249323 |
| EZH2 |
mediated by macrophages-stimulated PRMT1 |
promotes metastasis |
33092789 |
| FAM96A (CIAO2A) and FAM96B (CIAO2B) |
regulation of the Wnt/?-catenin signaling pathway |
tumor suppressor genes in breast cancer |
36165859 |
| FBXL10 (KDM2B) |
increases transcriptional activity of SNAI1, decreased expression levels of E-cadherin, inducing EMT |
promotes metastasis |
34718323 |
| FGF2 |
decreases APL leads to bone mineralisation |
invasive ductal carcinoma metastasis in females |
no data available |
| FGFR1 |
mutated (amplification) |
promotes metastasis |
28433771 |
| GAL1 |
increased levels in claudin-low BC |
promotes BC metastasis |
33166603 |
| GALNT8 |
regulates EGFR 0-GalNacylation |
decreased rate of BC meta |
35220009 |
| GLI2 |
HER2-mediated stabilization |
promotes metastasis of breast cancer cells |
30409762 |
| GPC3 |
p38 MAPK pathway activation |
inhibits metastasis |
32800275 |
| GPX1 |
FAK signaling |
regulates metastasis of triple-negative breast cancer |
31926619 |
| HIF1A |
no data available |
lymph node metastasis |
35074419 |
| HOXD9 |
epigenetic modification of RND3 |
breast cancer metastasis |
34767964 |
| HULC |
IGF1R-PI3K-Akt axis |
promote BC metastasis |
35981570 |
| IGDQ |
integrin (v)3 activation in MDA-MB-231 metastatic breast cancer cells |
nduces directional cell migration |
35763908 |
| IGF2BP2 |
Polymorphisms and mutation |
associated with Altered Risk of Breast Cancer metastasis |
36653207 |
| IL-39 |
circulation IL-39 in breast cancer was found to correlate negatively with migration potential |
Serum IL-39 provided potential early diagnostic performance indicators of breast cancer |
36865390 |
| IL32 |
integrin 3-p38 MAPK signalling |
promotes breast cancer metastasis |
30391782 |
| IL6 |
hijacks Er |
increases BC metastasis |
32679107 |
| IMP2 and IMP3 |
through destabilization of progesterone receptor |
promote the metastasis of triple-negative breast cancer |
29217458 |
| INSIG2 |
directly targets miR96 |
promotes BC metastasis in HER2- and TNBC |
33321090 |
| ITGA2 |
promotes expression of ACLY and CCND1 |
breast cancer metastasis |
34179312 |
| KIBRA (WWC1) |
Affected by Chromosome 5q Loss |
inhibits metastasis in Triple-Negative Breast Cancer |
29562176 |
| KIF17 |
silencing of the gene |
initiates BC metastasis in lung metastasis in MDA-MB-231 |
36089118 |
| KIF3C |
inhibiting TGF signaling |
inhibits metastasis in breast cancer |
26272184 |
| LGR6 |
wnt-catenin pathway |
enhanced TNBC metastasis |
32775619 |
| LOXL2 |
promotes LECs invasion via activating Akt and Erk pathways; tube formation |
promotes lymph node metastasis |
30925417 |
| MAP7D1 |
via 5hmc-mediated epigenetic regulation |
promotes lymph node metastasis |
33716151 |
| MAP7D1-1 |
Genome-wide 5-Hydroxymethylcytosine Profiling Analysis |
Novel Regulator of Lymph Node Metastasis in Breast Cancer |
33716151 |
| MAPK12 |
overexpressed |
promotes bone metastasis |
25066918 |
| MDIG (RIOX2) |
Deletion of mdig enhances H3K36me3 |
metastatic potential of the triple negative breast cancer cells |
36124233 |
| MET |
mutated (amplification) |
promotes metastasis |
30429039 |
| MFAP5 |
regulating ERK/MMP signaling pathways in breast cancer |
promotes tumor progression and bone metastasis |
29526753 |
| MIF |
activation of HMGB1/TLR4/NF kappa B axis |
promotes breast cancer metastasis |
26952810 |
| MMP13 |
|
Bone metastasis |
21784845 |
| MMP2 |
directly targeted by RAN-GTP pathway |
reduces metastasis |
36209829 |
| MUC1 |
overexpressed |
promotes metastasis |
23303343 |
| N4BP3 |
NEDD4-mediated E-cadherin ubiquitination and degradation |
promotes metastasis |
36162713 |
| NFIC |
through interferon-mediated Jak-STAT pathway |
suppresses migration in breast cancer |
35798053 |
| NLRP3 |
elevates ILB mediates EMT |
promotes metastasis |
33975248 |
| NNMT |
enhances PP2A/MEK/ERK/c-Jun/ABCA1 pathway mediated membrane fluidity |
enhances TNBC metastasis |
35988817 |
| NOG |
reinitiation through ID2 subsequently altering the levels of RANK |
Breast Cancer Bone Metastasis-supporting Gene |
22547073 |
| NPNT |
Integrin-Binding Motifs |
Promotes Metastasis |
29539586 |
| NQO1 and PKLR |
modulating glycolytic reprogramming |
lymph node metastasis |
30954648 |
| NRBE3 (PPP1R26) |
by down-regulating E-cadherin expression |
promotes metastasis of breast cancer |
30262434 |
| NRG1 |
via the c-Myc ubiquitination as manipulated by ERK1/2-mediated Fbxw7 phosphorylation |
promotes metastasis |
34992218 |
| NUPR1 |
Activated TEF3 transcription-mediated autophagy |
increases BC metastasis |
35660538 |
| OPN (SPP1) |
genistein on the regulation of osteopontin |
overexpression is associated with breast cancer metastasis |
Reference Link |
| OR5B21 |
Induce EMT through STAT3/NF-B/C/EBPB pathway |
BC brain metastasis |
34917897 |
| PAD1 (PSMD14) |
promotes metastasis in triple-negative breast cancer cells |
by regulating MEK1-ERK1/2-MMP2 signaling |
28844713 |
| PARD3 |
pull tension and protein nanoparticle-induced osmotic pressure |
promotes BC metastasis |
36179489 |
| PCDH7 |
|
induces bone metastasis of breast cancer |
23751349 |
| PDL1 (CD274) |
Asynchronous blockade of PD-L1 and CD155 by polymeric nanoparticles |
inhibits triple-negative breast cancer metastasis |
34186238 |
| PGC1A (PPARGC1A) |
overexpression and increased bioenergetic flexibility |
Promotes Breast Cancer Lung Metastasis |
28988825 |
| PIK3CA |
gene mutations |
promotes metastasis |
33842357 |
| PP1a |
E2F1-mediated ectopic expression, via activation of YAP1 |
promotes breast cancer metastasis |
36787863 |
| PRAME |
Knocking down of PRAME |
promotes breast cancer cell proliferation |
27632898 |
| PSAT1 |
Upregulated levels stabilises Notch-1 and B-catenin |
promotes distant metastasis |
35339029 |
| PTBP1 |
correlates with HER2 positivity |
ymph node spread and metastasis |
Reference Link |
| PTHRP (PTHLH) |
|
promotes BC bone metastasis |
33845139 |
| PTK2B |
invadopodia-mediated |
inhibits breast cancer metastasis |
36258022 |
| PYK2 (PTKB) |
cortactin-Pyk2 interaction affects invadopodia formation |
inhibits breast cancer metastasis |
Reference Link |
| RACGAP1 |
ECT2-Dependent mitochondrial quality control |
drive breast cancer metastasis |
33485843 |
| RAD51 |
overexpressed |
promotes lymph node metastasis |
24811120 |
| RANKL (TNFSF11) and RANK (TNFRSF11A) |
|
ex hormone-induced breast cancer and breast cancer metastasis |
21470874 |
| RB1 |
deficiency induces Mitochondrial OXPHOS |
causes metastasis |
29120753 |
| RBBP8 |
low or no expression of CtIP/RBBP8 |
high nodal metastasis |
24403251 |
| RBP2 |
RBP2 loss suppresses tumor formation |
inhibition of Breast Cancer Metastasis |
24582965 |
| RFC3 |
Up-Regulation of RFC3 Via EMT |
Promotes Triple Negative Breast Cancer Metastasis |
27888707 |
| RKIP |
through up-regulation of miR-185 targeting HMGA2 |
suppresses metastasis of breast cancer cell lines |
27651238 |
| ROBO4 |
through regulation of tumor angiogenesis |
suppresses breast cancer metastasis |
26778715 |
| ROCK1 |
Activate TMEM16A Ca2+-activated Cl channels |
promotes breast cancer metastasis |
34603794 |
| ROR-Gamma (RORC) |
Pathways |
Breast Cancer Metastasis |
27211549 |
| RUNX1 |
|
breast cancer mediated bone metastasis |
28268169 |
| S100A4 |
Extracellular ATP |
breast cancer cell migration and metastasis |
29733962 |
| SCAMP3 |
c-MYC-Catenin-SQSTM1 growth and stemness axis |
promotes breast cancer migration |
36627007 |
| SCN4B |
reducing 4 expression increases RhoA activity |
potentiates cell migration |
27917859 |
| SCN5A |
EF2-kinase signaling |
growth and lung metastasis of triple-negative breast cancer |
36526045 |
| SEC14L3 |
Wnt-catenin-related way |
inhibits BC metastasis |
35447102 |
| SEZ6L2 |
regulated by USF1 |
accelerates metastasis of breast cancer |
35523305 |
| SIRT5 |
via a gluocose-dependent manner promotes aerobic glycolysis |
promotes metastasis |
35576836 |
| SLIT2 |
Activating M1-Like Phagocytic and Antifibrotic Macrophages |
Inhibits Breast Cancer Metastasis |
34400395 |
| SLUG (SNAI2) |
Repression of Plakoglobin Gene by Metastasis Modulator Protein SLUG |
High Motility of Triple-negative Breast Cancer Cells |
22496452 |
| SMC1A |
regulated by KIAA1429 in m6A-independent manner |
promotes EMT and metastasis in breast cancer |
34976433 |
| SNAIL (SNAI1) |
HER2 mediated de novo production of TGF? |
metastasis of breast cancer |
24994678 |
| SOX2 |
increased levels FSCN1 and HBEGF |
increased metastasis |
32322668 |
| SP2043 |
by blocking IGF1R and Met signaling in lymphatic and blood endothelial cells |
inhibits triple negative breast cancer (TNBC) growth and metastasis |
25409905 |
| SPTBN1 |
Reduced expression of miR21 decreases EMT |
promotes metastasis |
34358482 |
| SQSTM1/p62 |
G0/G1 arrest along with immune cell infiltration |
promotes BC metastasis |
35873020 |
| SRP40 (SRSF5) |
overexpression affects CD44 splicing |
lymph node metastasis |
17651715 |
| STAT3 |
phosphorylation |
increases BC meta |
36170890 |
| STEAP1 |
Knockdown of STEAP1 expression enhanced cellular invasion and migration abilities, increased expression of EMT-related genes MMP2, MMP9, MMP13, VIM, and CDH2, and decreased CDH1 expression |
Increased expression inhibits metastasis |
30253922 |
| STMN1 |
phosphorylation-specific association of STMN1 with GRP78 |
promotes breast cancer metastasis |
27130664 |
| TFF1 |
increased expression in ER+ BC |
promotes BC bone metastasis |
33249323 |
| TGFB1 |
induces EMT and over expression of FAP |
promotes BC metastasis |
33741330 |
| TIPE2 |
CD8 +T and NK cell-mediated antitumor response |
decreased BC metastasis |
28314212 |
| TMEM126A |
knocked down TMEM126A regulates mitochondrial retrograde signaling |
promotes breast cancer metastasis |
30393159 |
| TP53 |
frequently mutated |
promotes metastasis |
Reference Link |
| TRIM25 |
coordinately regulates pro-metastatic networks at both the DNA and RNA levels |
Key Determinant of Breast Cancer Metastasis |
28813674 |
| TRPV6 |
increases NFATC2 transcriptional activity by increasing NFATC2IP phosphorylation, consequently upregulates ADAMTS6 expression |
promote breast cancer metastasis. |
34265397 |
| TWIST1 |
transcriptionally activates PDGFR |
increases metastasis |
33845139 |
| UBQLN1 |
Akt overexpression induces EMT |
promotes metastasis |
36271556 |
| VCAM-1 |
|
|
32829009 |
| VEGF-C & VEGF-D |
increased P212 high VEGF-C/VEGF-D
mRNA expression ratio in breast cancer |
lymph
node metastasis and recurrence. |
Reference Link |
| WASF3 |
regulating genetic pathways |
involved in BC metastasis |
31542393 |
| WWP1 |
|
decreases CXCL12-mediated MDA231 breast cancer cell migration and bone metastasis |
22266093 |
| YAP |
by repressing growth differentiation factor-15 |
promotes breast cancer metastasis |
29499325 |
| YB-1 |
targets cell-intrinsic PD-1/PD-L1 Pathway |
promotes metastasis |
36265523 |
| YD0514 |
Targeting the NRF-2/RHOA/ROCK signaling pathway |
suppress breast cancer lung metastasis |
29580806 |
| YTHDF3 |
translation of m6A-enriched gene transcripts |
BC brain metastasis |
33125861 |
| YTHDF3-1 |
Upregulated levels nduces the Translation of m6A-Enriched Gene Transcripts |
brain metastases in breast cancer |
33125861 |
| ZNF281 |
targets miR543 to form a feedback loop |
TGF induced BC metastasis |
32512343 |
| ZNF319 |
increased expression of E2F and G2/M related genes in ZNF319-silenced cells |
decreases metastasis |
34902746 |